丝裂原活化蛋白激酶活化的蛋白激酶2抗体
规格：1mg/1ml
英文名： MAPKAP Kinase 2
别名： MAP Kinase Activated Protein Kinase 2; MAPK activated protein kinase 2; MAPKAP kinase 2; MAPKAPK 2; MAPKAPK2; Mitogen Activated Protein Kinase Activated Protein Kinase 2; MK 2; MK2; MAPK2_HUMAN.
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MAPKAP K
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit,
细胞定位：细胞核 细胞浆
丝裂原活化蛋白激酶活化的蛋白激酶2抗体产品介绍：background: MAP kinase activated protein kinase 2 (MAPKAP Kinase 2), also known as p45 hsp27 kinase, is a 45-54 kDa serine/threonine protein kinase that contains a proline rich sequence and two putative SH3 binding sites. MAPKAP Kinase 2 is activated in response to stress, IL1 and TNF, possibly catalyzed by p38/Hog dependent phosphorylation. One of the major substrates of MAPKAP Kinase 2 is hsp27, which stimulates actin polymerization in order to facilitate recovery from destruction of cytoskeleton during cellular stresses. MAPKAP2 is implicated in several disorders including ischemic brain injury and heart failure and has been shown to be important in regulating stress resistance and the production of TNF alpha. Subunit: Heterodimer with p38-alpha/MAPK14. The heterodimer with 丝裂原活化蛋白激酶活化的蛋白激酶2抗体p38-alpha/MAPK14 forms a stable complex: molecules are positioned 'face to face' so that the ATP-binding sites of both kinases are at the heterodimer interface. Interacts with PHC2. Subcellular Location: Cytoplasm. Nucleus. Note=Phosphorylation and subsequent activation releases the autoinhibitory helix, resulting in the export from the nucleus into the cytoplasm. Tissue Specificity: Expressed in all tissues examined. Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Contains 1 protein kinase domain. Gene ID: 9261 Database links: Entrez Gene: 9261 Human Entrez Gene: 17164 Mouse Entrez Gene: 289014 Rat Omim: 602006 Human SwissProt: 丝裂原活化蛋白激酶活化的蛋白激酶2抗体P49137 Human SwissProt: P49138 Mouse Unigene: 643566 Human Unigene: 713747 Human Unigene: 221235 Mouse Unigene: 6276 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丝裂原活化蛋白激酶活化的蛋白激酶2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:10-200 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid