前列腺特异膜抗原抗体
规格：1mg/1ml
英文名： PMSA
别名： FOLH; PMSA; Cell growth inhibiting protein 27; FGCP; Folate hydrolase 1; folate hydrolase; Folate hydrolase prostate specific membrane antigen 1; FOLH 1; FOLH; FOLH1; Folylpoly gamma glutamate carboxy
分子量： 84kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PMSA
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞浆 细胞膜
前列腺特异膜抗原抗体产品介绍：background: PMSA (FOLH1) is a type II transmembrane glycoprotein belonging to the M28 peptidase family. Three functionally distinct proteins are encoded, including folylpoly-gamma-glutamate carboxypeptidase in the intestine, N-acetylated alpha-linked acidic dipeptidase 1 in the brain, and prostate-specific membrane antigen in the prostate. A mutation in the intestinal form may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. The form expressed in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. The prostate form is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants. Subunit: Homodimer. Subcellular Location: Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm. Tissue Specificity: Highly expressed in prostate epithelium. 前列腺特异膜抗原抗体Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most 前列腺特异膜抗原抗体abundant form in primary prostate tumors. Isoform PSMA-2 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer. Similarity: Belongs to the peptidase M28 family. M28B subfamily. Gene ID: 2346 Database links: Entrez Gene: 2346 Human Omim: 600934 Human SwissProt: Q04609 Human Unigene: 654487 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
前列腺特异膜抗原抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 细胞表面分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid