瞬时受体电位离子通道蛋白/M亚家族抗体
规格:1mg/1ml
英文名: TRPM2
别名: EREG 1; EREG1; TRPM2; TRPM2_HUMAN; Estrogen responsive element associated gene 1; Estrogen responsive element associated gene 1 protein; KNP 3; KNP3; Long transient receptor potential channel 2; LTRPC
分子量: 165kDa
储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型:Polyclonal
亚型:IgG
纯化方法:affinity purified by Protein A
**原:KLH conjugated synthetic peptide derived from human TRPM2
交叉反应:Human, Mouse, Rat, Horse,
细胞定位:细胞膜
瞬时受体电位离子通道蛋白/M亚家族抗体产品介绍:background: TRPM2 is a Ca(2+)-permeable channel that is activated by oxidative stress and confers susceptibility to cell death. Subunit: Isoform 1 can interact with isoform 3. This interaction decreases calcium influx through isoform 1 and suppresses susceptibility to oxidative stress-induced cell death. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in brain and peripheral blood cells, such as neutrophils. Also detected in bone marrow, spleen, heart, liver and lung. Isoform 2 is found in neutrophil granulocytes. Similarity: Belongs to the transient receptor (TC 1.A.4) family. LTrpC 瞬时受体电位离子通道蛋白/M亚家族抗体subfamily. TRPM2 sub-subfamily. Contains 1 nudix hydrolase domain. Gene ID: 7226 Database links: Entrez Gene: 7226 Human Entrez Gene: 28240 Mouse Entrez Gene: 294329 Rat Omim: 603749 Human SwissProt: O94759 Human 瞬时受体电位离子通道蛋白/M亚家族抗体SwissProt: Q5KTC0 Mouse SwissProt: Q91YD4 Mouse SwissProt: Q5G856 Rat Unigene: 369759 Human Unigene: 276762 Mouse Unigene: 214495 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. TRPM2 属于瞬时受体电位离子通道蛋白家族的M亚家族,是一种非选择性的阳离子通道蛋白, 是离子通道蛋白参与了单核细胞的氧化应激应答反应,与老年性痴呆等神经退行**的发生与发展有着十分密切的联系.
瞬时受体电位离子通道蛋白/M亚家族抗体产品应用:WB=1:100-500 ELISA=1:2000-5000 IHC-F=1:100-200 Flow-Cyt=1:100-200 IF=1:100-200 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域:**学 神经生物学 通道蛋白
储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源: Rabbit
外观: Lyophilized or Liquid