溶血磷脂酸受体蛋白1/EDG2抗体
规格：1mg/1ml
英文名： LPA1
别名： EDG 2; Endothelial Cell Differentiation Gene-2; Endothelial differentiation gene 2; Endothelial Differentiation Lysophosphatidic Acid G Protein Coupled Receptor 2; G10 protein homolog; GPCR 26; GPCR26
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EDG2/LPA
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
细胞定位：
溶血磷脂酸受体蛋白1/EDG2抗体产品介绍：background: EDG2 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. There are eight known members of the EDG receptor family and they are implicated in mediating growth-related effects such as induction of cellular proliferation, alterations in differentiation and survival, and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C, and several proteins not used within 12 hours. Edg2 has been reported in most human tissues, and is especially abundant in brain cortical regions. ESTs have been isolated from bone, brain, breast, connective tissue, embryo, heart/melanocyte/uterus, lung, prostate and uterus libraries. Function: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Stimulates phospholipase C (PLC) activity in a manner that is dependent on RALA activation. Subunit: Interacts 溶血磷脂酸受体蛋白1/EDG2抗体with RALA and ADRBK1. Subcellular Location: Cell surface. Cell membrane; Multi-pass membrane protein. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA co-localizes with RALA in the endocytic vesicles. Tissue Specificity: Expressed in many ***** organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, and kidney. Little or no expression in liver, lung, thymus, or peripheral blood leukocytes. Similarity: Belongs to the G-protein coupled receptor 1 family.溶血磷脂酸受体蛋白1/EDG2抗体 Gene ID: 1902 Database links: Entrez Gene: 281136 Cow Entrez Gene: 1902 Human Entrez Gene: 14745 Mouse Entrez Gene: 116744 Rat Omim: 602282 Human SwissProt: Q28031 Cow SwissProt: Q92633 Human SwissProt: P61793 Mouse SwissProt: P61794 Rat SwissProt: P46628 Sheep Unigene: 126667 Human Unigene: 4772 Mouse Unigene: 11200 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
溶血磷脂酸受体蛋白1/EDG2抗体产品应用：WB=1:100-500 ELISA=1:2000-5000 IHC-P=1:100-500 IHC-F=1:30-200 ICC=1:30-200 IF=1:30-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 信号转导 G蛋白偶联受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid