G蛋白信号转导调节因子5抗体
规格：1mg/1ml
英文名： RGS5
别名： MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129; Regulator of G Protein Signalling 5; RGS 5; RGS5_HUMAN.
分子量： 22kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse RGS5
交叉反应：Human, Mouse, Rat, Dog, Pig, Rabbit,
细胞定位：
G蛋白信号转导调节因子5抗体产品介绍：background: Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi and Gq class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. RGS5 seems to be an important signalling regulator in the vascular system. Present data suggest that RGS5 may be involved in the regulation of capillary growth, angiogenesis, and in the pathophysiology of stroke. Function: Inhibits signal transduction by increasing the GTPase activity of G protein G蛋白信号转导调节因子5抗体alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. Similarity: Contains 1 RGS domain. Gene ID: 8490 Database links: Entrez Gene: 8490 Human Entrez Gene: 19737 Mouse Entrez Gene: 54294 Rat Omim: 603276 Human SwissProt: O15539 Human SwissProt: O08850 Mouse SwissProt: Q864Z2 Pig SwissProt: P49800 Rat Unigene: G蛋白信号转导调节因子5抗体24950 Human Unigene: 20954 Mouse Unigene: 1150 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. RGS5是调控G-蛋白活性的信号蛋白（RGS）家族的一员，是肿瘤血管形成的一个重要调控因子.主要与G蛋白α亚基结合，发挥GTP酶激活蛋白（GAPs）作用，负性调节G蛋白信号传导途径。Rgs5在体内多个器官都有表达，主要表达于这些组织器官的血管周细胞。 近期发现，Rgs5与血管的生成、发展及成熟有密切关系，影响全身各系统功能。同时在一些肿瘤组织和细胞中也有高表达，且与肿瘤血管的异常有关。Rgs5基因的缺失可以使得肿瘤血管正常化，并促进****的效果，提示其可能成为抗肿瘤血管**的新靶点。另外RGS5也可能是一种肿瘤相关抗原．对肿瘤诊断及**有着积极的意义．
G蛋白信号转导调节因子5抗体产品应用：WB= ELISA= IHC-P= IHC-F= IF= （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liqui