IL-2诱导型T细胞激酶抗体
规格：1mg/1ml
英文名： ITK
别名： EMT; Homolog of mouse T cell itk/tsk; IL2 inducible T cell kinase; Kinase EMT; LYK; MGC126257; MGC126258; PSCTK 2; PSCTK2; T cell specific kinase; TSK; Tyrosine protein kinase; Tyrosine protein kinase
分子量： 68kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ITK/PSCT
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
IL-2诱导型T细胞激酶抗体产品介绍：background: This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008] Function: Plays a role in T-cell proliferation and differentiation. Subcellular Location: Cell membrane. Localizes to cell surface receptors in the plasma membrane after stimulation with respective receptors (TCR, CD28, CD2) in T-cells. Tissue Specificity: T-cell lines and natural killer cell lines. DISEASE: Defects in ITK are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1) [MIM:613011]. LPSA1 is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV).IL-2诱导型T细胞激酶抗体 Inadequate immune response to EBV can have a fatal outcome. Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk for lymphoma. Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. Contains 1 Btk-type zinc finger. Contains 1 PH domain. Contains 1 protein kinase IL-2诱导型T细胞激酶抗体domain. Contains 1 SH2 domain. Contains 1 SH3 domain. Gene ID: 3702 Database links: Entrez Gene: 3702 Human Entrez Gene: 16428 Mouse Entrez Gene: 363577 Rat Omim: 186973 Human SwissProt: Q08881 Human SwissProt: Q03526 Mouse Unigene: 558348 Human Unigene: 339927 Mouse Unigene: 145244 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
IL-2诱导型T细胞激酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 信号转导 细胞凋亡 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid