接头蛋白Gab 1抗体
规格:1mg/1ml
英文名: Gab1
别名: GRB 2 associated binder 1; GRB 2 associated binding protein 1; GRB2 associated binding protein 1 isoform a; GRB2 associated binding protein 1 isoform bl; Gab 1; Gab1; GAB1_HUMAN; GRB2 associated binde
分子量: 76kDa
储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型:Polyclonal
亚型:IgG
纯化方法:affinity purified by Protein A
**原:KLH conjugated synthetic peptide derived from human Gab1
交叉反应:Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位:
接头蛋白Gab 1抗体产品介绍:background: Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus, activating mitogenic as well as other responses. Critical components of this process include adapter proteins such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity (1-3,8). Gab1 can be phosphorylated by multiple receptor tyrosine kinase (RTKs), including: insulin receptor (IR), platelet derived growth factor receptor beta] (PDGFRbeta]), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c Met), and epidermal growth factor receptor (EGF), as well as in response to cell cell adhesion. Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphoatidylinositol 3 kinase (PI3K), Grb2, PLC gamma 1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2, and for activation of the ERK/MAPK pathway in response to EGF. Function: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1接头蛋白Gab 1抗体 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Subunit: Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Similarity: Belongs to the GAB family. Contains 1 PH domain. Gene ID: 2549 Database links: Entrez Gene: 2549 Human Entrez Gene: 14388 Mouse Entrez Gene: 361388 Rat Omim: 604439 Human SwissProt: Q13480 Human SwissProt: Q9QYY0 Mouse Unigene: 618456 Human Unigene: 80720 Human Unigene: 接头蛋白Gab 1抗体277409 Mouse Unigene: 1725 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Gab1作为一种分布广泛的接头蛋白,几乎能连接所有类型的受体(如酪氨酸激酶受体、G-蛋白偶联受体、细胞因子与抗原受体等,Gab1蛋白属于接头蛋白Gab家族,该家族蛋白因能与生长因子受体结合蛋白2(Grb2)相结合而得名。作为接头蛋白,Gab1蛋白能被多种受体酪氨酸激酶或非受体酪氨酸激酶激活,接受胞外多种生长因子、细胞因子和一些T/B细胞抗原受体的刺激,介导PI3K/Akt和Ras/MAPK等多条信号转导途径,具有促进细胞生长、迁移、调节**等多种生物学功能,与糖尿病、肿瘤、心血管**等的发**展密切相关。
接头蛋白Gab 1抗体产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域:肿瘤 细胞生物 信号转导 细胞凋亡 细胞周期蛋白 激酶和磷酸酶 细胞膜受体 细胞分化
储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源: Rabbit
外观: Lyophilized or Liquid