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胸腺基质淋巴细胞生成素受体抗体

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产品名称: 胸腺基质淋巴细胞生成素受体抗体
产品型号: CRLF2
产品展商: 单克隆抗体/多克隆抗体
产品文档: 无相关文档

简单介绍

胸腺基质**细胞生成素受体抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。胸腺基质**细胞生成素受体抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产品质量,质量稳定,实验效果明显。


胸腺基质淋巴细胞生成素受体抗体  的详细介绍

胸腺基质**细胞生成素受体抗体

规格:1mg/1ml

英文名: CRLF2

别名: TSLPR; CRLF2; CRL 2; CRL2; CRLF 2; CRLF2Y; Cytokine receptor CRL2 precusor; Cytokine receptor like 2; Cytokine receptor like factor 2; Cytokine receptor like factor 2 precursor; IL XR; ILXR; Thymic st

分子量: 38kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:Polyclonal

亚型:IgG

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human CRLF2

交叉反应:Human,

胸腺基质**细胞生成素受体抗体细胞定位:细胞膜 分泌型蛋白

产品介绍:background: TSLPR is a type I membrane receptor that forms a functional heterodimeric complex with IL7R to bind TSLP. The TSLP R contains a WSXWS motif required for proper protein folding and a box1 motif important for association with the JAKs. TSLPR has a predicted molecular weight approximately 41 kD, and two further isoforms have been reported that are produced by alternative splicing. The TSLPR is expressed preferentially in myeloid cells including dendritic cells and activated monocytes, and is weakly expressed in T cells. Expression has also been reported in heart, skeletal muscle, and kidney tissues. TSLP binding to the heterodimeric functional receptor (TSLPR and IL7R) activates JAK2, STAT3 and STAT5 to stimulate cell proliferation. Ligand receptor interactions haves been implicated in the development of the胸腺基质**细胞生成素受体抗体 hematopoietic system, dendritic cell maturation, and the maintenance and polarization of human Th2 memory T cells in allergic diseases. Function: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. Subunit: Heterodimer of CRLF2 and IL7R. Subcellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein (Probable). Isoform 2: Secreted (Probable). Tissue Specificity: Expressed in heart, skeletal muscle, kidney and ***** and fetal liver. Primarily 胸腺基质**细胞生成素受体抗体expressed in dendrites and monocytes. Weakly expressed in T-cells. Similarity: Belongs to the type I cytokine receptor family. Type 5 subfamily. Contains 1 fibronectin type-III domain. Gene ID: 64109 Database links: Entrez Gene: 64109 Human Omim: 300357 Human Omim: 400023 Human SwissProt: Q9HC73 Human Unigene: 287729 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胸腺基质**细胞生成素受体抗体产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:**学  细胞膜受体  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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