Toll样受体9抗体
规格：1mg/1ml
英文名： TLR9
别名： Toll-like receptor 9; CD 289; CD289; TLR 9; Toll like receptor 9; Toll like receptor 9 isoform A precursor; Toll like receptor 9 isoform B; TLR9_HUMAN.
分子量： 113kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TLR9
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆 细胞膜
Toll样受体9抗体产品介绍：background: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008] Function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation,Toll样受体9抗体 cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. Subunit: Interacts with MYD88 via their respective TIR domains. Interacts with CNPY3. Interacts (via transmembrane domain) with UNC93B1. Interacts with BTK. Subcellular Location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome. Lysosome. Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. Tissue Specificity: Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells.Toll样受体9抗体 Also detected in lung and liver. Similarity: Belongs to the Toll-like receptor family. Contains 26 LRR (leucine-rich) repeats. Contains 1 TIR domain. Gene ID: 54106 Database links: Entrez Gene: 54106 Human Entrez Gene: 81897 Mouse Entrez Gene: 338457 Rat Omim: 605474 Human SwissProt: Q9NR96 Human SwissProt: Q9EQU3 Mouse Unigene: 87968 Human Unigene: 44889 Mouse Unigene: 92495 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Toll样受体-9(Toll-like receptor 9,TLR9)是哺乳动物TLRs家族中一员,作为细胞表面的天然模式识别受体,主要参与**刺激序列(CpG序列)激活**细胞的信号传导,从而在天然抗感染**及联系天然**和获得性**中发挥重要作用。
产Toll样受体9抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学 信号转导 细胞周期蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid