Toll样受体6抗体
规格：1mg/1ml
英文名： TLR6
别名： CD286; CD286 antigen; TLR 6; Toll like receptor 6 precursor; TLR6_HUMAN; Toll-like receptor 6.
分子量： 84kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TLR6
交叉反应：Human, Mouse, Rat, Pig, Horse,
细胞定位：细胞浆 细胞膜
Toll样受体6抗体产品介绍：background: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Toll样受体6抗体Jan 2011] Subunit: Binds TLR2 via their respective extracellular domains. Binds MYD88 via their respective TIR domains. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Tissue Specificity: Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells. Similarity: Belongs to the Toll-like receptor family. Contains 12 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 TIR domain. Gene ID: 10333Toll样受体6抗体 Database links: Entrez Gene: 10333?/span>Human Entrez Gene: 21899?/span>Mouse Omim: 605403?/span>Human SwissProt: Q9Y2C9?/span>Human SwissProt: Q9EPW9?/span>Mouse Unigene: 575090?/span>Human Unigene: 42146?/span>Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Toll样受体6抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-2000 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞膜受体
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid