唾液酸结合性**球蛋白样凝集素抗体
规格：1mg/1ml
英文名： SIGLEC10
别名： PRO940; mSiglec G; Sialic acid binding Ig like lectin 10; Sialic acid binding Ig like lectin 10; sialic acid binding Ig like lectin 10 Ig like lectin 7; sialic acid binding Ig like lectin G; Sialic ac
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SIGLEC10
交叉反应：Human, Mouse, Rat, Dog, Pig,
细胞定位：细胞膜 分泌型蛋白
唾液酸结合性**球蛋白样凝集素抗体产品介绍：background: SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002] Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Subunit: Interacts with PTPN6/SHP-1 upon phosphorylation.唾液酸结合性**球蛋白样凝集素抗体 Subcellular Location: Isoform 1, 2, 3, 4: Cell membrane; Single-pass type I membrane protein. Isoform 5: Secreted. Tissue Specificity: Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells. Post-translational modifications:唾液酸结合性**球蛋白样凝集素抗体 Phosphorylation of Tyr-667 is involved in binding to PTPN6. Similarity: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Gene ID: 89790 Database links: Entrez Gene: 89790 Human Omim: 606091 Human SwissProt: Q96LC7 Human Unigene: 284813 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
唾液酸结合性**球蛋白样凝集素抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:10-100 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 自然杀伤细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid