神经丛蛋白A1抗体
规格：1mg/1ml
英文名： Plexin A1
别名： NOV; NOV/plexin A1 protein; NOVP; Plexin1; PlexinA1; PLXN1; PLXNA1; PLXNA1; protein; Semaphorin receptor NOV; PLXA1_HUMAN.
分子量： 206kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Plexin A
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Guinea Pig,
神经丛蛋白A1抗体细胞定位：细胞膜
产品介绍：background: Plexins are a family of large integral membrane proteins that complex with neuropilins to form semaphorin co-receptors. The extracellular region of plexins contain a semaphorin domain, multiple glycine rich motifs, and MET related sequences. The cytoplasmic region contains a Sex/Plexin domain and putative tyrosine phosphorylation sites that mediate signal transduction after activation. This region in Plexin A1 binds the RhoGTPases, Rnd1 and RhoD. Recruitment of Rnd1 has been implicated in the cytoskeletal collapse that occurs after semaphorin mediated activation of Plexin A1, while RhoD may block this collapsing activity through interaction with the cytoplasmic region of Plexin A1. The expression of Plexin A1, along with the co receptor Neuropilin 1, is upregulated in neurons after central nervous system injury. The axons from these neurons cannot cross semaphorin 3A containing regions at the site of injury. Thus, semaphorin 3A and its co-receptors, Plexin A1 and Neuropilin 1, may have significant roles in axon regeneration after neuronal injury. Function: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D神经丛蛋白A1抗体. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Subunit: Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation 神经丛蛋白A1抗体of FARP2. Subcellular Location: Cell membrane (Probable); Single-pass type I membrane protein. Tissue Specificity: Detected in fetal brain, lung, liver and kidney. Similarity: Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 1 Sema domain. Gene ID: 5361 Database links: Entrez Gene: 5361 Human Entrez Gene: 18844 Mouse NCBI: NP_115618 Human Omim: 601055 Human SwissProt: Q9UIW2 Human SwissProt: P70206 Mouse Unigene: 432329 Human Unigene: 549421 Human Unigene: 3789 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Plexins是一种单途径、具有多向潜在功能的跨膜蛋白，为Sema-phorins（神经信号蛋白）家族的受体,PlexinA1蛋白主要定位于细胞质和细胞膜，Semaphorins的很多重要的生理作用均是通过Plexins信号传导来发挥作用的。PlexinA1在神经系统形成、心血管生成、胚胎发生和**反应等方面发挥重要作用。
神经丛蛋白A1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 **学 发育生物学 神经生物学 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid