细胞粘附分子CD112抗体
规格：1mg/1ml
英文名： CD112
别名： Nectin-2; Nectin2; Nectin 2; CD 112; CD112; CD112 antigen; Herpes virus entry mediator B; Herpes virus entry protein B; Herpesvirus entry mediator B; Herpesvirus entry protein B; Hve B; HveB; Poliovir
分子量： 56kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CD112
交叉反应：Human, Mouse, Rat, Cow, Horse,
细胞定位：细胞膜
细胞粘附分子CD112抗体产品介绍：background: Nectin 2 is a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Can form trans-heterodimers with PVRL3/nectin-3. Function: Probable cell adhesion protein. Subunit: Can form trans-heterodimers with PVRL3/nectin-3. Interacts with CD226. Binds with low affinity to TIGIT. Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these细胞粘附分子CD112抗体 viruses. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Ubiquitous. Similarity: Belongs to the nectin family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Gene ID: 5819 Database links: Entrez Gene: 5819 Human Entrez Gene: 19294 Mouse Entrez Gene: 308417 Rat Omim: 600798 Human SwissProt: Q92692 Human SwissProt: P32507 Mouse Unigene: 655455 Human Unigene: 4341 Mouse Unigene: 203297 Rat Important Note: This product as supplied is 细胞粘附分子CD112抗体intended for research use only, not for use in human, therapeutic or diagnostic applications. 细胞粘附分子Nectin-2（CD112）是一种同源性非钙依赖型的CAM，属**球蛋白超家族，由nectin-1、nectin-2、nectin-3组成，广泛存在于肿瘤、正常细胞，神经细胞、内皮细胞等，CD112也是单纯疱疹病毒(HSV-1和HSV-2)的受体，具有同型或异型细胞粘附活性.在多发性硬化中呈现高表达。
细胞粘附分子CD112抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 神经生物学 细胞粘附分子 细胞表面分子 内皮细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid