鞘氨醇激酶1抗体
规格：1mg/1ml
英文名： SPHK1
别名： sphingosine kinase 1; SK 1; SK1; SPHK 1; SPHK; SPK; SPK 1; SPK1; Sphk1; SPHK1_HUMAN.
分子量： 42-52kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SPHK1
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit,
细胞定位：
鞘氨醇激酶1抗体产品介绍：background: The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] Function: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra-and extracellular functions. Also acts on D-erythro-sphingosine and to a鞘氨醇激酶1抗体 lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. Tissue Specificity: Widely expressed with highest levels in ***** liver, kidney, heart and skeletal muscle. Similarity: Contains 1 DAGKc domain. Gene ID: 8877 Database links: Entrez Gene: 8877 Human Entrez Gene: 20698 Mouse Entrez Gene: 170897 Rat Omim: 鞘氨醇激酶1抗体603730 Human SwissProt: Q9NYA1 Human SwissProt: Q8CI15 Mouse SwissProt: Q91V26 Rat Unigene: 68061 Human Unigene: 20944 Mouse Unigene: 18522 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. SPHK1参与鞘氨醇代谢、G蛋白偶联受体蛋白信号转导途径，有抗细胞凋亡的作用，可被蛋白激酶C激活，参与细胞内信号转导级联、钙介导信号转导、调控细胞生长迁移、调控血管生成及成纤维细胞增殖。
鞘氨醇激酶1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导 细胞凋亡 激酶和磷酸酶 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid