白细胞相关**球蛋白样受体1抗体
规格：1mg/1ml
英文名： LAIR-1
别名： Leukocyte-associated immunoglobulin-like receptor 1; LAIR1; CD305; 5133400O11Rik; D7Bwg0421e; LAIR1 protein; Leukocyte associated Ig like receptor 1; Leukocyte associated immunoglobulin like receptor
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse LAIR-1
交叉反应：Mouse, Rat,
细胞定位：细胞膜
白细胞相关**球蛋白样受体1抗体产品介绍：background: The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. [provided by RefSeq]. Function: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, downregulating IL2 and IFNG production while inducing secretion 白细胞相关**球蛋白样受体1抗体of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells. Subunit: Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed on the majority白细胞相关**球蛋白样受体1抗体 of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in na飗e T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection. Post-translational modifications: Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK. N-glycosylated. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Gene ID: 52855 Database links: Entrez Gene: 3903 Human Entrez Gene: 52855 Mouse Omim: 602992 Human SwissProt: Q6GTX8 Human SwissProt: Q8BG84 Mouse Unigene: 572535 Human Unigene: 290880 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. LAIR1属于细胞黏附分子中**球蛋白超家族（IgSF）成员，是一种**细胞抑制性受体，定位于T细胞、B细胞、NK细胞及树状突等多种细胞中。
白细胞相关**球蛋白样受体1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞膜受体
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid