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NK细胞抑制性受体2DL4抗体

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产品名称: NK细胞抑制性受体2DL4抗体
产品型号: CD158D
产品展商: 单克隆抗体/多克隆抗体
产品文档: 无相关文档

简单介绍

NK细胞抑制性受体2DL4抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。NK细胞抑制性受体2DL4抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产品质量,质量稳定,实验效果明显。


NK细胞抑制性受体2DL4抗体  的详细介绍

NK细胞抑制性受体2DL4抗体

规格:1mg/1ml

英文名: CD158D

别名: Killer cell immunoglobulin-like receptor 2DL4; MHC class I NK cell receptor KIR103AS; KIR103; CD158d; CD158 antigen like family member D; CD158D; G9P; Killer cell immunoglobulin like receptor, two dom

分子量: 39kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:Polyclonal

亚型:IgG

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human CD158 C-

交叉反应:Human,

细胞定位:

NK细胞抑制性受体2DL4抗体产品介绍:background: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while NK细胞抑制性受体2DL4抗体KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants. [provided by RefSeq] Function: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis. Subunit: Interacts with ARRB2. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Similarity: NK细胞抑制性受体2DL4抗体Belongs to the immunoglobulin superfamily. Contains 2 Ig-like C2-type (immunoglobulin-like) Database links: Entrez Gene: 3805 Human Omim: 604945 Human SwissProt: Q99706 Human Unigene: 651287 Human Unigene: 661219 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

NK细胞抑制性受体2DL4抗体产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:**学  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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