白细胞介素-18受体α链抗体
规格：1mg/1ml
英文名： IL-18R alpha
别名： interleukin-18 receptor alpha chain; IL18R alpha; Interleukin-18 receptor 1; IL-18R-1; IL-18R1; IL1 receptor-related protein; interleukin 1 receptor-like protein; IL-1Rrp; IL1R-rp; CD218 antigen-like
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IL-18R a
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,
细胞定位：细胞膜
白细胞介素-18受体α链抗体产品介绍：background: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] Function: Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B. Subunit: Does not bind IL1A/interleukin-1 alpha or IL1B/interleukin-1 beta. 白细胞介素-18受体α链抗体Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression in Hodgkin disease cell lines. Similarity: Belongs to the interleukin-1 receptor family. Contains 3 Ig-like C2-type白细胞介素-18受体α链抗体 (immunoglobulin-like) domains. Contains 1 TIR domain. Gene ID: 8809 Database links: Entrez Gene: 8809 Human Omim: 604494 Human SwissProt: Q13478 Human Unigene: 469521 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
白细胞介素-18受体α链抗体产品应用：WB=1:100-500 ELISA=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-300 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid