产品资料
  首页 >>> 产品目录 >>> **学 >>> 单克隆抗体

白介素15受体α抗体

如果您对该产品感兴趣的话,可以
产品名称: 白介素15受体α抗体
产品型号: IL15RA
产品展商: 单克隆抗体/多克隆抗体
产品文档: 无相关文档

简单介绍

白介素15受体α抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。白介素15受体α抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产品质量,质量稳定,实验效果明显。


白介素15受体α抗体  的详细介绍

白介素15受体α抗体

规格:1mg/1ml

英文名: IL15RA

别名: Interleukin-15 receptor subunit alpha; IL 15R alpha; IL15RA; IL-15RA; Interleukin 15 receptor alpha; Interleukin 15 receptor subunit alpha; Soluble interleukin 15 receptor subunit alpha; I15RA_HUMAN.

分子量: 25kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:Polyclonal

亚型:IgG

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human IL-15RA

交叉反应:Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,

细胞定位:细胞核 细胞浆 细胞膜 细胞外基质 分泌型蛋白

白介素15受体α抗体产品介绍:background: IL15RA is a cytokine receptor that specifically binds IL15 with high affinity. It shares two subunits with the receptor of IL2, the IL2R beta and IL2R gamma chains. This forms the basis of many overlapping biological activities of IL15 and IL2. The IL2 receptor requires an additional IL2-specific alpha subunit for high affinity IL2 binding. This protein is structurally related to IL2R alpha, but is capable of binding IL15 with high affinity independent of other subunits, which suggests the distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. There are nine different isoforms. Function: High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 (By similarity) and SYK. Subunit: The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (By similarity). Interacts with SYK. Subcellular Location: Membrane. Nucleus membrane; Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with 白介素15受体α抗体the nuclear membrane. Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space. Tissue Specificity: Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures. Post-translational modifications: A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor白介素15受体α抗体. Phosphorylated by activated SYK. N-glycosylated and O-glycosylated. Similarity: Contains 1 Sushi (CCP/SCR) domain. Gene ID: 3601 Database links: Entrez Gene: 3601 Human Omim: 601070 Human SwissProt: Q13261 Human Unigene: 524117 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

白介素15受体α抗体产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:**学  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


产品留言
标题
联系人
联系电话
内容
验证码
点击换一张
注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!