白介素1受体2抗体
规格：1mg/1ml
英文名： IL-1R2
别名： IL1 Receptor II; IL-1R II; IL1 Receptor 2; interleukin-1 receptor type 2 precursor; IL1R2; CD121b; IL1RB; CD121; CD121 antigen-like family member B; CD121b; CD121B Antigen; CDW121B; IL-1R-2; IL-1R-bet
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IL-1R II
交叉反应：Human, Mouse, Rat, Dog,
细胞定位：
白介素1受体2抗体产品介绍：background: The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4(IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq]. Function: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for 白介素1受体2抗体neutralization of IL1B by secreted/soluble receptors. Subcellular Location: Isoform Short: Secreted. Isoform Long: Cell membrane; Single-pass type I membrane protein. Post-translational modifications: A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported. Similarity: Belongs to the interleukin-1 receptor family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Gene ID: 7850 Database links: Entrez 白介素1受体2抗体Gene: 7850 Human Omim: 147811 Human SwissProt: P27930 Human Unigene: 25333 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. IL-1RⅡ属于新的信号受体家族Toll信号转导通路蛋白，IL-1RⅡ在**和炎症反应的研究中占重要地位，是在很多感染 、炎症性致病机制中起决定性作用的细胞因子，几乎可作用于全身各种细胞，IL-1 与IL-1RⅡ的结合可导致大量与**反应和炎症相关基因的表达 ，包括细胞因子、细胞因子受体、急性期反应物、生长因子、胞外基质、粘附分子等。IL-1RⅡ/NF-κB信号通路是机体**反应中十分重要的组成部分。
白介素1受体2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 干细胞 **细胞 b-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid