离子通道蛋白Kv3.3抗体
规格：1mg/1ml
英文名： KCNC3
别名： Kv3.3; potassium voltage gated channel, Shaw-related subfamily, member 3; KSHIIID; KV3.3; Potassium voltage gated channel subfamily C member 3; SCA13; Shaw related subfamily, member 3; Shaw related vo
分子量： 81kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Kv33
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
细胞定位：
离子通道蛋白Kv3.3抗体产品介绍：background: The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. [provided by RefSeq]. Function: This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Subunit: Heterotetramer of potassium channel proteins. Subcellular Location: Membrane; Multi-pass membrane protein. DISEASE: Spinocerebellar ataxia 13 (SCA13) [MIM:605259]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders离子通道蛋白Kv3.3抗体. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA13 is an autosomal dominant cerebellar ataxia (ADCA) characterized by slow progression and variable age at onset, ranging from childhood to late *****hood. Mental retardation can be present in some patients. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the potassium channel family. C (Shaw) 离子通道蛋白Kv3.3抗体(TC 1.A.1.2) subfamily. Kv3.3/KCNC3 sub-subfamily. Gene ID: 3748 Database links: Entrez Gene: 3748 Human Entrez Gene: 16504 Mouse Entrez Gene: 117101 Rat Omim: 176264 Human SwissProt: Q14003 Human SwissProt: Q63959 Mouse SwissProt: Q01956 Rat Unigene: 467146 Human Unigene: 40312 Mouse Unigene: 9885 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产离子通道蛋白Kv3.3抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学 通道蛋白 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid