免疫球蛋超家族成员8抗体
规格：1mg/1ml
英文名： IGSF8
别名： CD316; CD316 antigen; CD81 partner 3; CD81P3; EWI-2; EWI2; Glu-Trp-Ile EWI motif-containing protein 2; igsf-8; IgSF8; IGSF8_MOUSE; Immunoglobulin superfamily member 8; Immunoglobulin superfamily membe
分子量： 62kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
免疫原：KLH conjugated synthetic peptide derived from mouse IGSF8
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse,
细胞定位：
免疫球蛋超家族成员8抗体产品介绍：background: IGSF8 is a 65kDa single-pass membrane protein that may play a key role in many of the functions attributed to CD81 and CD9, like Hepatitis C infection and oocyte fertilization. It is also believed that this protein acts as a negative regulator of cell motility (e.g. T-cell mobility, prostate cancer cell migration) and is involved in the regulation of neurite outgrowth and maintenance of the neural network in the brain. Function: May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the r免疫球蛋超家族成员8抗体egulation of neurite outgrowth and maintenance of the neural network in the ***** brain. Subunit: Interacts directly with CD82 and CD9/tetraspanin-29. Also interacts with integrin alpha-3/beta-1 and integrin alpha-4/beta-1. Interacts with CD81/tetraspanin-28. Subcellular Location: Cell membrane; Single-pass membrane protein. Tissue Specificity: Expressed in lymphocytes as well as in many tissues with higher免疫球蛋超家族成员8抗体 expression in brain. Detected in all regions of the brain with weak expression in the pituitary. Expressed selectively by neurons but not by glial cells. Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains. Gene ID: 140559 Database links: Entrez Gene: 93185 Human Entrez Gene: 140559 Mouse Omim: 606644 Human SwissProt: Q969P0 Human SwissProt: Q8R366 Mouse Unigene: 332012 Human Unigene: 271717 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
免疫球蛋超家族成员8抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-100 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 免疫学 微生物学 **及病毒
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid