诱导协同刺激分子CD278抗体
规格：1mg/1ml
英文名： ICOS
别名： Activation inducible lymphocyte immunomediatory molecule; Activation-inducible lymphocyte immunomediatory molecule; AILIM; CD278; CD278 antigen; CVID1; ICOS; ICOS_HUMAN; Inducible costimulator; Induci
分子量： 20kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ICOS
交叉反应：Human, Mouse, Rat, Pig,
细胞定位：细胞膜 分泌型蛋白
诱导协同刺激分子CD278抗体产品介绍：background: The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.[provided by RefSeq, Jul 2008]. Function: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). Subunit: Homodimer; disulfide-linked. Subcellular Location: Isoform 1: Cell membrane; Single-pass type I 诱导协同刺激分子CD278抗体membrane protein (Potential).Isoform 2: Secreted (Potential). Tissue Specificity: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. Post-translational modifications: N-glycosylated. DISEASE: Defects in ICOS are the cause of immunodeficiency common variable type 1 (CVID1) [MIM:607594].诱导协同刺激分子CD278抗体 CVID1 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be lo. Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain. Gene ID: 29851 Database links: Entrez Gene: 29851 Human Entrez Gene: 54167 Mouse Entrez Gene: 64545 Rat Omim: 604558 Human SwissProt: Q9Y6W8 Human SwissProt: Q9WVS0 Mouse SwissProt: Q9R1T7 Rat Unigene: 56247 Human Unigene: 42044 Mouse Unigene: 168816 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
诱导协同刺激分子CD278抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞膜受体 t-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid