CD226抗体
规格：1mg/1ml
英文名： CD226
别名： DNAX accessory molecule 1; adhesion glycoprotein; CD226 antigen; DNAM1; platelet and T cell activation antigen 1; PTA1; TLiSA1; CD226; CD226 molecule; CD226_HUMAN; DNAM 1; DNAM-1; T lineage specific a
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CD226
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
细胞定位：细胞膜
CD226抗体产品介绍：background: This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq, Jul 2008] Subunit: Interacts with PVR and PVRL2. Subcellular Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed by peripheral blood T-lymphocytes. Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Gene ID: CD226抗体10666 Database links: Entrez Gene: 10666 Human Omim: 605397 Human SwissProt: Q15762 Human Unigene: 660130 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD226分子是一种广泛表达于多种**细胞膜表面的Ⅰ型跨膜糖蛋白，CD226广泛表达于T细胞、NK细胞、NK T细胞、活化的血管内皮细胞、巨核/血小板谱系、单核细胞、胸腺细胞、某些B细胞亚群、部分造血干细胞和肥大细胞等**细胞表面，在**系统以外则分布于海马和小脑皮质的神经突触部位。CD226与其配体的相互作用参与CTL和NK细胞的活化、分化和细胞毒作用,调节CD4+ T细胞的增殖和分化，介导内皮细胞与其他细胞的黏附,促进血小板的活化与聚集，CD226抗体参与造血调控，介导肥大细胞的脱颗粒作用，参与NK T细胞和胸腺细胞的抗凋亡作用、树突状细胞的成熟、**突触和神经突触的形成，并与肿瘤、自身**性**、移植排斥及病毒感染等**密切相关。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
CD226抗体研究领域：**学 细胞粘附分子 细胞表面分子 细胞类型标志物 自然杀伤细胞 **细胞 t-**细胞 b-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid