C型凝集素结构域家族4成员A抗体
规格：1mg/1ml
英文名： DCIR
别名： C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 6; C type lectin; C type lectin DDB27; C type lectin superfamily 6; C-type (calcium dependent, carbohydrate-recogni
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DCIR
交叉反应：Human, Mouse, Rat, Dog, Pig, Guinea Pig,
细胞定位：细胞膜
C型凝集素结构域家族4成员A抗体产品介绍：background: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008] Function: May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calciumC型凝集素结构域家族4成员A抗体 mobilization and protein tyrosine phosphorylation. Subunit: May interact with PTPN6 via its ITIM motif. Subcellular Location: Membrane; Single-pass type II membrane protein. Tissue Specificity: Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was C型凝集素结构域家族4成员A抗体decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha). Similarity: Contains 1 C-type lectin domain. Gene ID: 50856 Database links: Entrez Gene: 50856 Human Omim: 605306 Human SwissProt: Q9UMR7 Human Unigene: 504657 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
C型凝集素结构域家族4成员A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 **学 信号转导 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid