心肌营养素1抗体
规格：1mg/1ml
英文名： CT-1
别名： cardiotrophin-1; Cardiophin1; Cardiotrophin 1; Cardiotrophin I; CardiotrophinI; CT1; CTF 1; CTF1; CTF1_HUMAN.
分子量： 21kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CT-1
交叉反应：Human, Mouse, Rat,
细胞定位：分泌型蛋白
心肌营养素1抗体产品介绍：background: Cardiotrophin-1 (CT-1), a cardiac hypertrophic factor, is a 21.5 kDa protein member of the IL-6 cytokine family. CT-1 is associated with the pathophysiology of heart diseases, including hypertension, myocardial infarction, valvular heart disease, and congestive heart failure. The protein exerts its cellular effects by interacting with the glycoprotein 130 (gp130)/leukemia inhibitory factor receptor beta (LIFR) heterodimer. In addition, CT-1 activates phosphatidylinositol 3-kinase (PI-3 kinase) in cardiac myocytes and enhances transcription factor NF kappa B DNA -binding activities. CT-1 is highly expressed in the heart, skeletal muscle, prostate and ovary and to 心肌营养素1抗体lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Function: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor. Subcellular Location: Secreted. Tissue Specificity: Highly expressed in heart, skeletal muscle, prostate and ovary. Lower levels in lung, kidney, pancreas, thymus, testis and small intestine. Little or no expression in brain, placenta, liver, spleen, 心肌营养素1抗体colon or peripheral blood leukocytes. Similarity: Belongs to the IL-6 superfamily. Gene ID: 1489 Database links: Entrez Gene: 1489 Human Entrez Gene: 29201 Rat Omim: 600435 Human SwissProt: Q16619 Human SwissProt: Q63086 Rat Unigene: 483811 Human Unigene: 10253 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产心肌营养素1抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid