CD23/FcεRII抗体
规格：1mg/1ml
英文名： CD23
别名： Fc EpsilonR II; FcεRII; Blast 2; Blast2; C type lectin domain family 4 member J; C-type lectin domain family 4, member J; CD 23; CD 23A; CD23 antigen; CD23A; CLEC 4J; CLEC4J; Fc epsilon RII; Fc fragme
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CD23
交叉反应：Human, Mouse, Rat, Horse, Rabbit,
细胞定位：细胞膜 分泌型蛋白
CD23/FcεRII抗体产品介绍：background: The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a “membrane bound cytokine," in that the soluble cleavage products of CD23 are themselves able to act as cytokines in CD23/FcεRII抗体vitro. Function: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). Subcellular Location: Cell membrane; Single-pass type II membrane protein. Secreted. Note=Also exists as a soluble excreted form. Post-translational modifications: N- and O-glycosylated. Similarity: Contains 1 C-type lectin domain. Gene ID: 2208 Database links: Entrez Gene: 2208 Human Entrez Gene: 14128 Mouse Omim: 151445 Human SwissProt: P06734 Human CD23/FcεRII抗体SwissProt: P20693 Mouse Unigene: 465778 Human Unigene: 1233 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CD23是一种II型跨膜糖蛋白，是存在于B细胞表面的IgE受体。在慢性B**细胞白血病（CLL）和小B细胞**瘤（SLL）为阳性，套细胞**瘤和小核裂**细胞**瘤阴性。也表达于外周血B细胞的某些亚型、B**细胞和EB病毒转染的B**瘤细胞系。CD23是慢性B**细胞白血病，小B细胞**瘤诊断和鉴别诊断有用的标记物。
CD23/FcεRII抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 干细胞 细胞类型标志物 **细胞 t-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid