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B细胞活化因子受体抗体

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产品名称: B细胞活化因子受体抗体
产品型号: BAFFR
产品展商: 单克隆抗体/多克隆抗体
产品文档: 无相关文档

简单介绍

B细胞活化因子受体抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。B细胞活化因子受体抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产品质量,质量稳定,实验效果明显。


B细胞活化因子受体抗体  的详细介绍

B细胞活化因子受体抗体

规格:1mg/1ml

英文名: BAFFR

别名: B Cell Activating Factor Receptor; B-cell-activating factor receptor; BAFF R; BAFF receptor; BAFF-R; BAFFR; BLyS receptor 3; BlySR3; BR 3; BR3; BROMIX; CD 268; CD268; CD268 antigen; CVID4; MGC138235;

分子量: 19kDa

储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型:Polyclonal

亚型:IgG

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human BAFFR

交叉反应:Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,

B细胞活化因子受体抗体细胞定位:细胞膜

产品介绍:background: B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq]. Function: B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLySB细胞活化因子受体抗体. Promotes the survival of mature B-cells and the B-cell response. Subcellular Location: Membrane; Single-pass type III membrane protein (Probable). Tissue Specificity: Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. DISEASE: Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiencyB细胞活化因子受体抗体 characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. Similarity: Contains 1 TNFR-Cys repeat. Gene ID: 115650 Database links: Entrez Gene: 115650 Human Entrez Gene: 72049 Mouse Entrez Gene: 500910 Rat Omim: 606269 Human SwissProt: Q96RJ3 Human SwissProt: Q9D8D0 Mouse Unigene: 344088 Human Unigene: 240047 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

B细胞活化因子受体抗体产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:细胞生物  信号转导  生长因子和**  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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