诱导协同刺激分子配体CD275抗体
规格：1mg/1ml
英文名： ICOS ligand
别名： B7 H2; B7 homolog 2; B7 homologue 2; B7 like protein Gl50; B7 related protein 1; B7-like protein Gl50; B7-related protein 1; B7-H2; B7H2; B7RP 1; B7RP-1; B7RP1; CD 275; CD275; CD275 antigen; GL 50; GL
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ICOS lig
交叉反应：Human, Rat,
细胞定位：细胞膜
诱导协同刺激分子配体CD275抗体产品介绍：background: ICOS ligand is a member of the B7 family and the immunoglobulin superfamily. Human ICOS ligand is expressed by activated monocytes/macrophages and dendritic cells. It binds to a CD28 like receptor, inducible costimulator molecule (ICOS, AILIM, CRP-1), which is expressed by activated T cells. This interaction plays an important role in the T cell costimulation pathway. Function: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. Subunit: Membrane; 诱导协同刺激分子配体CD275抗体Single-pass type I membrane protein. Subcellular Location: Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. Similarity: Belongs to the immunoglobulin superfamily. BTN/MOG family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.诱导协同刺激分子配体CD275抗体 Gene ID: 23308 Database links: Entrez Gene: 23308 Human Entrez Gene: 50723 Mouse Omim: 605717 Human SwissProt: O75144 Human SwissProt: Q9JHJ8 Mouse Unigene: 14155 Human Unigene: 17819 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. B7协同刺激分子及其相应受体结合所产生的信号在调节T细胞活化及效应性细胞因子分泌中起重要作用，具有负性调节作用的协同刺激分子对**应答的适度进行、防止自身****的发生具有重要作用。 B7H2可协同刺激CD14 + 细胞增殖，并分泌IL-4、IL-5、IFN-诱导协同刺激分子配体CD275抗体β、TNF-α、GM-CSF和IL-10等细胞因子，但不能协同刺激T细胞上调IL-2的分泌。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 转录调节因子 细胞表面分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid