巨噬细胞炎性蛋白19抗体
规格:1mg/1ml
英文名: CCL19
别名: Macrophage Inflammatory Protein 3β; ;Macrophage Inflammatory Protein 3 beta; Beta chemokine exodus 3; C C chemokine ligand 19; CC chemokine ligand 19; CCL19; Chemokine (C C motif) ligand 19; Chemokine
分子量: 9.2kDa
储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型:Polyclonal
亚型:IgG
纯化方法:affinity purified by Protein A
**原:KLH conjugated synthetic peptide derived from mouse CCL19
交叉反应:Human, Mouse, Rat, Pig,
细胞定位:细胞外基质
巨噬细胞炎性蛋白19抗体产品介绍:background: This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Jul 2008] Function: Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating 巨噬细胞炎性蛋白19抗体T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Specifically binds to chemokine receptor CCR7. Subcellular Location: Secreted. Tissue Specificity: Highly expressed by dendritic cells in mesenteric and peripheral lymph nodes. Significant expression in spleen (T cell zone or periarteriolar lymphatic sheath) and Peyer patches. Low expression in thymus. Similarity巨噬细胞炎性蛋白19抗体: Belongs to the intercrine beta (chemokine CC) family. Gene ID: 24047 Database links: Entrez Gene: 6363 Human Entrez Gene: 100039053 Mouse Entrez Gene: 24047 Mouse Omim: 602227 Human SwissProt: Q99731 Human SwissProt: O70460 Mouse Unigene: 50002 Human Unigene: 426373 Mouse Unigene: 441169 Mouse Unigene: 459263 Mouse Unigene: 6660 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
巨噬细胞炎性蛋白19抗体产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域:细胞生物 **学 自然杀伤细胞
储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源: Rabbit
外观: Lyophilized or Liquid