多效生长因子抗体
规格：1mg/1ml
英文名： Pleiotrophin
别名： pleiotrophin; HARP; HBBM; HBGAM; HBGF8; HBNF; HBNF1; Heparin Binding Growth Factor 8; Heparin binding neurite outgrowth promoting factor 1; heparin-binding growth associated molecule; NEGF1; Neurite G
分子量： 15kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PTN
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit,
细胞定位：
多效生长因子抗体产品介绍：background: Pleiotrophin is a heparin-binding growth factor involved in the differentiation and proliferation of neuronal tissue during embryogenesis, and also secreted by melanoma and breast carcinoma cells. Pleiotrophin exhibits mitogenic and angiogenic properties and has been shown to influence the vascular supply, expansion and metastasis of tumour cells. Function: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. Subunit:多效生长因子抗体 Interacts with ALK and NEK6. Subcellular Location: Secreted. Tissue Specificity: Osteoblast and brain. Post-translational modifications: Phosphorylated by NEK6. Similarity: Belongs to the pleiotrophin family. Gene ID: 5764 Database links: Entrez Gene: 5764 Human 多效生长因子抗体Entrez Gene: 19242 Mouse Entrez Gene: 24924 Rat Omim: 162095 Human SwissProt: P21246 Human SwissProt: P63089 Mouse SwissProt: P63090 Rat Unigene: 371249 Human Unigene: 279690 Mouse Unigene: 1653 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 多效生长因子(pleiotrophin）是一种分泌性的生长因子,具有促进肿瘤细胞的增殖与迁移，对肿瘤血管的生成有促进作用。
多效生长因子抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 信号转导 生长因子和** 细胞骨架 细胞外基质
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid