细胞死亡调节蛋白抗体
规格：1mg/1ml
英文名： AVEN
别名： 1700013A01Rik; 1700056A21Rik; mAven L; mAven S; MGC124011; Apoptosis caspase activation inhibitor; Cell death regulator Aven; OTTMUSP00000016129; PDCD12; Programmed cell death 12; RP23-52C15.2; AVEN_H
分子量： 38kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human AVEN
交叉反应：Human, Mouse, Rat, Chicken, Pig, Horse, Rabbit,
细胞定位：细胞膜
细胞死亡调节蛋白抗体产品介绍：background: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. AVEN is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that AVEN functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that AVEN impedes Apaf-1-mediated caspase activation. Higher levels of AVEN mRNA are seen in patients with acute leukemia than in control patients, suggesting that AVEN may be useful as a prognostic indicator in leukemia patients. Function: Protects against apoptosis mediated by Apaf-1 Subunit: Binds Apaf-1, BCL-2 细胞死亡调节蛋白抗体and BAD (Bcl-xl) Subcellular Location: Endomembrane system; Peripheral membrane protein. Note=Associated with intracellular membranes. Tissue Specificity: Highly expressed in testis, ovary, thymus, prostate, spleen, small intestine, colon, heart, skeletal muscle, liver, kidney and pancreas. Gene ID: 57099 Database links: Entrez Gene: 57099 Human Entrez Gene: 74268 Mouse Entrez Gene: 311299 Rat Omim: 605265 细胞死亡调节蛋白抗体Human SwissProt: Q9NQS1 Human SwissProt: Q9D9K3 Mouse Unigene: 555966 Human Unigene: 315125 Mouse Unigene: 436657 Mouse Unigene: 145049 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞死亡调节蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid