TNF家族B细胞激活因子抗体
规格：1mg/1ml
英文名： BAFF
别名： ApoL related ligand TALL 1; B cell Activating Factor; B lymphocyte stimulator ; BLYS; CD 257; CD257; CD257 antigen; delta BAFF; Dendritic cell derived TNF like molecule; DTL; DTL precursor; TALL 1; TA
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse BAFF
交叉反应：Human, Mouse, Rat, Pig, Cow, Rabbit,
细胞定位：细胞膜 分泌型蛋白
TNF家族B细胞激活因子抗体产品介绍：background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. [provided by RefSeq]. Function: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B-and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Subunit: Belongs to the tumor necrosis factor family. Subcellular Location: Secreted and Cell membrane. Tissue Specificity: Abundantly expressed inTNF家族B细胞激活因子抗体 peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Post-translational modifications: The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. Similarity: Belongs to the tumor necrosis factor family. Gene ID: 24099 Database links: Entrez Gene: 10673 Human Entrez Gene:TNF家族B细胞激活因子抗体 24099 Mouse Omim: 603969 Human SwissProt: Q9Y275 Human SwissProt: Q9WU72 Mouse Unigene: 525157 Human Unigene: 596110 Human Unigene: 28835 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TNF家族B细胞激活因子抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 细胞凋亡 生长因子和** 激酶和磷酸酶 细胞分化 b-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid