脂肪炎症因子Apelin抗体
规格：1mg/1ml
英文名： Apelin
别名： AGTRL1 ligand; APEL; APEL_HUMAN; Apelin-13; Apelin13; Apelin 13; APJ endogenous ligand; Apln; XNPEP2.
分子量： 10kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Apelin
交叉反应：Human, Mouse, Rat,
细胞定位：分泌型蛋白
脂肪炎症因子Apelin抗体产品介绍：background: Apelin is a neuropeptide expressed in the supraoptic and paraventricular nuclei and is an endogenous ligand for APJ, a G protein-coupled orphan receptor which is an alternative coreceptor with CD4 for HIV-1. Apelin and APJ are ubiquitously expressed in peripheral tissues, with highest levels reported for heart and lungs, as well several regions within the central nervous system. The actions of apelin remain largely unknown: Apelin inhibits HIV-1 entry in cells coexpressing CD4 and APJ; the oral intake of Apelin in colostrum and breast milk could have a role in the modulation of the immune responses in neonates; more recent studies have also indicated a role for Apelin in the central control of body fluid homeostasis, by influencing AVP release and drinking behavior. In the cardiovascular system several actions of Apelin have been described, including endothelium-dependent vasodilatation, vasoconstriction through direct action on smooth muscle and positive inotropism. Function: Endogenous ligand for APJ, an alternative coreceptor with CD4 for HIV-1 infection. Inhibits HIV-1 entry in cells coexpressing CD4 and APJ. Apelin-36 has a greater inhibitory activity on HIV infection than other synthetic apelin derivatives. The oral intake in the colostrum and the 脂肪炎症因子Apelin抗体milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior. Subcellular Location: Secreted. Tissue Specificity: Expressed in the brain with highest levels in the frontal cortex, thalamus, hypothalamus and midbrain. Secreted by the mammary gland into the colostrum and the milk. Post-translational modifications: Several active peptides may be produced by proteolytic processing of the peptide precursor. Similarity: Belongs to the脂肪炎症因子Apelin抗体 apelin family. Gene ID: 8862 Database links: Entrez Gene: 8862 Human Entrez Gene: 30878 Mouse Entrez Gene: 58812 Rat Omim: 300297 Human SwissProt: Q9ULZ1 Human SwissProt: Q9R0R4 Mouse SwissProt: Q9R0R3 Rat Unigene: 303084 Human Unigene: 29262 Mouse Unigene: 22847 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 脂肪炎症因子apelin是血管紧张素Ⅱ-1型受体相关蛋白的天然内源性配体，是新发现的小分子活性多肽，为孤儿G蛋白偶联受体一血管紧张素受体AT-1相关蛋白(APJ)的天然配体具有调节心血管系统稳态、扩张血管、降低血压、调节**等多种生物学作用。
脂肪炎症因子Apelin抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid