钾离子通道蛋白EAG1抗体
规格：1mg/1ml
英文名： KCNH1
别名： EAG1; EAG 1; EAG-1; KCNH 1; KCNH-1; h eag; Kv10.1; MGC124420; MGC142269; EAG; Ether a go go potassium channel 1; hEAG1; M eag; MGC124419; Potassium voltage gated channel subfamily H (eag related), mem
分子量： 111kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human KCNH1
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞膜
钾离子通道蛋白EAG1抗体产品介绍：background: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]. Function: Pore-forming (alpha) subunit of voltage-gated non-inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in钾离子通道蛋白EAG1抗体 myoblasts. Subunit: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. Heteromultimer with KCNH5/EAG2. Interacts with ALG10B (By similarity). Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells. Similarity: Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv10.1/KCNH1 sub-subfamily. Contains 1 cyclic nucleotide-binding domain. Contains 1 PAC (PAS-associated C-terminal) domain. Contains 1 PAS (PER-ARNT-SIM) domain. Gene ID: 3756 Database links: Entrez Gene: 3756 Human Entrez Gene: 16510 Mouse Entrez Gene: 65198 Rat Omim: 603305 Human SwissProt: O95259 Human SwissProt: Q60603 Mouse SwissProt: Q63472 钾离子通道蛋白EAG1抗体Rat Unigene: 553187 Human Unigene: 4489 Mouse Unigene: 11071 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. KCNH1钾通道蛋白在调控细胞增殖和细胞周期进程中起重要作用。Eag1是膜蛋白, 参与细胞信号转导, 在正常组织和恶性肿瘤中有独特的表达特点. 一些离子通道如钾、钙、氯、钠等通道与肿瘤相关，特别是钾通道与肿瘤的关系*为密切。钾通道是细胞膜上种类*多、*为复杂的一类离子通道，它存在于多种细胞中，是细胞膜电位的重要控制因素。
钾离子通道蛋白EAG1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-200 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞周期蛋白 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid