穿膜蛋白DLK1抗体
规格：1mg/1ml
英文名： DLK1
别名： Adipocyte differentiation inhibitor protein; Brevideltin; Delta like 1 homolog; Delta like homolog; Delta like protein; Delta1; DLK 1; DLK; DLK-1; Dlk1; DLK1_HUMAN; FA 1; FA1; Fetal antigen 1; pG2; Pr
分子量： 42kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DLK1
交叉反应：Human, Mouse, Rat, Pig, Rabbit, Sheep,
细胞定位：细胞膜
穿膜蛋白DLK1抗体产品介绍：background: This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010]. Function: May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation. Subunit: Monomer. Subcellula穿膜蛋白DLK1抗体r Location: Membrane; Single-pass type I membrane protein. Tissue Specificity: Highly expressed in fetal liver, placenta, ***** adrenal gland, brain, testis and ovary and, to a lesser degree, in ***** kidney, muscle, thymus and heart. Post-translational modifications: N- and O-glycosylated. Similarity: Contains 6 EGF-like domains. Gene ID: 8788 Database links: Entrez Gene: 8788 Human Entrez Gene: 13386 Mouse Entrez Gene: 114587 Rat Omim: 176290 Human SwissProt: P80370 Human SwissProt: Q09163 Mouse Unigene: 533717 Human Unigene: 157069 Mouse Unigene: 14547 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 穿膜蛋白DLK1抗体穿膜蛋白DLK1又称肝癌相关基因，是表皮生长因子(EGF)家族的成员之一,其结构特征为蛋白的细胞外区域拥有在结构及氨基酸序列上与表皮生长因子高度同源的重复结构.DLK1可以抑制脂肪前体细胞向脂肪细胞分化,在正常神经***细胞及其肿瘤细胞中表达, DLK1在神经***轴中起着调控细胞生长分化的作用,同时DLK1在胚胎肝、造血干细胞及早期肌肉组织中均有表达。
穿膜蛋白DLK1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 神经生物学 信号转导 干细胞 转录调节因子 结合蛋白 细胞表面分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid