细胞毒性受体NK-p44抗体
规格：1mg/1ml
英文名： NCR2
别名： Natural killer cell p44-related protein; CD336; CD336 antigen; LY95; Lymphocyte antigen 95 homolog; Lymphocyte antigen 95 (activating NK receptor; NK p44); Natural cytotoxicity triggering receptor 2;
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CD336
交叉反应：Human,
细胞定位：细胞膜
细胞毒性受体NK-p44抗体产品介绍：background: NCR2 (NKp44) is a member of the natural cytotoxicity receptor (NCR) family that is expressed on activated human NK cells. NCR2 displays a single extracellular Ig-like V domain and a transmembrane portion containing the charged residue (Lysine), likely involved in the association with KARAP/DAP12 molecules. Gene coding for NCR2 maps on human chromosome 6p21.1 Function: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Subunit: Interacts with TYROBP/DAP12. Subcellular Location: Cell membrane; Single-pass type I membrane protein (Potential). Tissue Specificity: Selectively expressed by activated NK cells and by in vitro cultured (i.e. activated) TCRg/d lymphoid cells. Similarity: 细胞毒性受体NK-p44抗体Belongs to the natural cytotoxicity receptor (NCR) family. Contains 1 Ig-like (immunoglobulin-like) domain. Gene ID: 9436 Database links: Entrez Gene: 9436 Human GenBank: NM_004828 Human Omim: 604531 Human SwissProt: O95944 Human Unigene: 194721 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 细胞毒性受体家族细胞毒性受体NK-p44抗体（NCRs）主要有：NKp46、NKp44和NKp30，其中NKp46和NKp30表达于所有静止和活化的NK细胞，而NKp44则选择性的表达于活化的NK细胞。靶细胞上的配体分子与NCRs的结合（交联）引发NK细胞的活化导致靶细胞的裂解和大量细胞因子的产生。现已确认NKp46和NKp44可以识别病毒上的配体分子红血球凝聚素，而NKp46则能识别肿瘤细胞上的乙酰硫酸多聚糖。
细胞毒性受体NK-p44抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 细胞膜受体 自然杀伤细胞 t-**细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid