雄**结合蛋白抗体
规格：1mg/1ml
英文名： ABP
别名： Androgen binding protein; MGC126834; MGC138391; SBP; Sex steroid binding protein; SHBG; TEBG; Testis specific androgen binding protein; Testosterone binding beta globulin; Testosterone Estradiol Bindi
分子量： 40kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ABP
交叉反应：Human, Mouse, Rat, Dog, Cow, Rabbit,
细胞定位：分泌型蛋白
雄**结合蛋白抗体产品介绍：background: Sex hormone binding globulin (SHBG) is a glycoprotein synthesized by the liver. Circulating androgen and estrogen concentrations influence SHBG synthesis. Elevated testosterone, for example, causes SHBG synthesis to decrease, whereas high estrogen stimulates SHBG production. The regulation of SHBG synthesis, combined with SHBG's higher affinity for testosterone, impacts bioavailable testosterone levels. SHBG binds up to 98 percent of the steroid hormones in the blood including 5a-dihydrotestosterone (DHT), testosterone and androstenediol with particularly high affinity, and estradiol and estrone with slightly lower affinity. Function: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their 雄**结合蛋白抗体plasma concentration. Subunit: Homodimer. Subcellular Location: Secreted (By similarity). Note=In testis, it is synthesized by the Sertoli cells, secreted into the lumen of the seminiferous tubule and transported to the epididymis (By similarity). Tissue Specificity: Isoform 1 and isoform 2 are present in liver and testis. Similarity: Contains 2 laminin G-like domains. Gene ID: 6462 Database links: Entrez Gene: 404182 Cow Entrez Gene: 6462 Human Omim: 182205 Human SwissProt: P04278 Human Unigene: 632235 Human Important Note: This product as supplied is intended for雄**结合蛋白抗体 research use only, not for use in human, therapeutic or diagnostic applications. 雄**结合蛋白ABP是一种由睾丸支持细胞合成和分泌的与雄**有高度亲和力的蛋白,雄**是依赖于雄**结合蛋白起作用的,ABP与睾酮或双氢睾酮结合后，转运至曲细精管，提高雄**在曲细精管的局部浓度，有利于生精过程。
雄**结合蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 生长因子和** ***病 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid