突触泡蛋白2A抗体
规格：1mg/1ml
英文名： SV2A
别名： Synaptic vesicle protein 2A; Synaptic vesicle glycoprotein 2A; Synaptic vesicle protein 2A; Synaptic vesicle protein 2; Sv2; Kiaa0736; SV2A_HUMAN.
分子量： 83kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SV2A
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞浆 细胞膜
突触泡蛋白2A抗体产品介绍：background: SV2s (Synaptic Vesicle protein 2) are integral membrane glycoproteins present in all synaptic vesicles. They have 12 transmembrane domains predicted by sequence analysis. There are three characterized isoforms, SV2A, SV2B and SV2C. SV2A is expressed ubiquitously throughout the brain. SV2B has a more restricted distribution with varying degrees of coexpression with SV2A. SV2C is more closely related to SV2A but shows a very restricted expression pattern. The highest expression levels were observed in phylogenetically old brain areas like pallidum, the midbrain and the olfactory bulb. SV2A is probably involved in the maintenance of a pool of synaptic vesicles competent for calcium-stimulated exocytosis. SV2A is a highly glycosylated synaptic vesicle protein with homology to transmembrane transporters. Function: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission.突触泡蛋白2A抗体 Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity). Subunit: Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2. Subcellular Location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Post-translational modifications: Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1. N-glycosylated. Similarity: Belongs to the major facilitator superfamily. Gene ID: 9900 Database links: Entrez突触泡蛋白2A抗体Gene: 9900 Human Entrez Gene: 64051 Mouse Entrez Gene: 117559 Rat Omim: 185860 Human SwissProt: Q29397 Cow SwissProt: Q7L0J3 Human SwissProt: Q9JIS5 Mouse SwissProt: Q02563 Rat Unigene: 516153 Human Unigene: 200365 Mouse Unigene: 11264 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 突触泡蛋白2A(SV2A)是一类跨膜糖蛋白,定位于脊椎动物神经元及***细胞,与神经递质的释放、***泡胞吐作用、突触泡稳态的维持作用。
产突触泡蛋白2A抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：神经生物学 细胞膜受体 糖蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid