ATP结合转运因子2抗体
规格：1mg/1ml
英文名： TAP2
别名： ABC18; ABCB3; Peptide supply factor 2; Peptide transporter PSF2; Peptide transporter TAP2; PSF2; RING 11; TAP 2; Transporter 2 ATP binding cassette sub family B.
分子量： 75kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TAP2 (48
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞膜
ATP结合转运因子2抗体产品介绍：background: TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It is a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP is inducible by interferon gamma and belongs to the ABC transporter family, MDR subfamily. TAP also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAPATP结合转运因子2抗体 complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding. Subunit: Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a. Subcellular Location: Membrane; Multi-pass membrane protein. Similarity: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter ATP结合转运因子2抗体(TC 3.A.1.209) subfamily. Contains 1 ABC transmembrane type-1 domain. Contains 1 ABC transporter domain. Gene ID: 6891 Database links: Entrez Gene: 6891?/span>Human Omim: 170261?/span>Human SwissProt: Q03519?/span>Human Unigene: 502?/span>Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ATP结合转运因子2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:25-400 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 信号转导 转录调节因子
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid