神经节苷酯抗体
规格：1mg/1ml
英文名： ganglioside GM1
别名： GM1 ganglioside; Monosialoanglioside; ganglioside GM1.
分子量： 1.57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated GM1 purified ganglioside from pig
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞浆 细胞膜
产神经节苷酯抗体品介绍：background: A member of the family of glycosphingolipids, monosialoanglioside acts as a receptor and antigen for cholera. GM1 ganglioside, one of the glycosphingolipids widely distributed in all tissues, occurs in highest concentrations in the central nervous system (CNS). It is primarily located in the outer surface of the mammalian cell's plasma membrane and in synaptic membranes of the CNS. GM1 ganglioside modulates a number of cell surface and receptor activities as well as neuronal differentiation and development,神经节苷酯抗体 protein phosphorilation and synaptic function. Subcellular Location: Plasma membrane Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 含有唾液酸的鞘脂类。克伦克（E.Klenk，1935）首先发现在患Tay－sachs病（泰萨氏幼年型黑白痴病）的小儿脑中有蓄积（Tag－Sachs gangli-oside），在脑灰白质中含量很多，所以对这类糖脂命名为神经节苷脂神经节苷酯抗体。已知糖部分是由己糖、氨基糖、唾液酸组成的脑神经节苷脂有8种以上。由山川民夫（1951）在马血球基质中找到的非神经系统的神经节苷脂——主要是血苷脂[hematoside，结构为神经酰胺（1←1β）GLc（4←1β）Gal（3←2α）唾液酸]。神经节苷脂较多地存在于细胞膜，以其与膜功能的关系被引起重视。破伤风菌和霍乱菌的外**可与特定的神经节苷脂分子特异性结合。在水和有机溶剂中可溶。在水中是以数百万个分子聚合的微团状态存在。 神经节苷脂对神经再生有重大促进作用。加拿大金爵集团脑科学研究室**科学家Gatte Walker博士进一步研究发现，神经生长因子（NGF）和神经节苷脂（GM）是脑神经再**育必需物质，GM介导NGF数十倍增强其活性，形成新的丰富的神经网络，修复并促使脑神经再次发育。 GM能够介导神经生长因子NGF促进脑神经****，表现出良好的生物效应。——《西安交通医科大学学报》。
神经节苷酯抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 细胞表面分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid