RNA聚合酶I抗体
规格:1mg/1ml
英文名: UBF1
别名: UBF; NOR 90; Nucleolar transcription factor 1; UBF 1; UBF-1; UBF; UBTF; Autoantigen NOR-90; Upstream-binding factor 1; Upstream binding factor 1; upstream binding transcription factor, RNA polymerase
分子量: 89kDa
储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型:Polyclonal
亚型:IgG
纯化方法:affinity purified by Protein A
**原:KLH conjugated synthetic peptide derived from human UBF1
交叉反应:Human, Mouse, Rat, Cow,
细胞定位:细胞核
RNA聚合酶I抗体产品介绍:background: This gene encodes a member of the HMG-box DNA-binding protein family. The encoded protein plays a critical role in ribosomal RNA transcription as a key component of the pre-initiation complex, mediating the recruitment of RNA polymerase I to rDNA promoter regions. The encoded protein may also play important roles in chromatin remodeling and pre-rRNA processing, and its activity is regulated by both phosphorylation and acetylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3, 11 and X and the long arm of chromosome 11.RNA聚合酶I抗体 [provided by RefSeq, Aug 2011] Function: Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. Subcellular Location: Nucleus Post-translational modifications: Phosphorylated and activated by PIK3CA. Similarity: Contains 6 HMG box RNA聚合酶I抗体DNA-binding domains. Gene ID: 7343 Database links: Entrez Gene: 7343 Human Entrez Gene: 21429 Mouse Entrez Gene: 25574 Rat Omim: 600673 Human SwissProt: P17480 Human SwissProt: P25976 Mouse SwissProt: P25977 Rat Unigene: 89781 Human Unigene: 2845 Mouse Unigene: 22469 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
RNA聚合酶I抗体产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域:肿瘤 细胞生物 **学 染色质和核信号 转录调节因子
储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源: Rabbit
外观: Lyophilized or Liquid