肥大细胞类糜蛋白酶1抗体
规格：1mg/1ml
英文名： Mast Cell Chymase
别名： CHYMASE; Alpha-chymase; Chymase 1; Chymase 1 mast cell; Chymase; Chymase, heart; Chymase, mast cell; CMA1; CMA1_HUMAN; CYH; CYM; EC 3.4.21.39; Mast cell chymase 1; Mast cell protease 3; Mast cell prot
分子量： 25kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Mast Cel
交叉反应：Human, Mouse, Rat, Sheep, Guinea Pig, G
细胞定位：细胞浆 分泌型蛋白
肥大细胞类糜蛋白酶1抗体产品介绍：background: This gene product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. This gene maps to 14q11.2 in a cluster of genes encoding other proteases. [provided by RefSeq, Jul 2008] Function: Major 肥大细胞类糜蛋白酶1抗体secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion. Subcellular Location: Secreted. Cytoplasmic granule. Note=Mast cell granules. Tissue Specificity: Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions. Similarity: Belongs to the peptidase S1 family. 肥大细胞类糜蛋白酶1抗体Granzyme subfamily. Contains 1 peptidase S1 domain. Gene ID: 1215 Database links: Entrez Gene: 1215 Human Omim: 118938 Human SwissProt: P23946 Human Unigene: 135626 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肥大细胞类糜蛋白酶1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:20-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 细胞生物 **学 信号转导 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid