孤儿核受体PAR1抗体
规格：1mg/1ml
英文名： PXR
别名： BXR; NR1I2; Nuclear receptor subfamily 1 group I member 2; ONR 1; ONR1; Orphan nuclear receptor PAR 1; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; PAR 1; PAR 2; PAR; PAR q; PAR1; PAR2;
分子量： 48kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PXR
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse,
细胞定位：细胞核
孤儿核受体PAR1抗体产品介绍：background: The human nuclear pregnane X receptor (PXR) activates cytochrome P450-3A expression in response to a wide variety of xenobiotics and plays a critical role in mediating dangerous drug-drug interactions. The human PXR is related to the mouse Pxr1, which they had cloned and shown to be activated by dexamethasone, pregnenolone 16-alpha-carbonitrile (PCN), and other compounds known to induce expression of the CYP3A1 gene, the predominant form of CYP3A in rat liver and intestine. Northern blot analysis detected most abundant expression in liver, colon, and small intestine; transcripts of 2.6, 4.3, and 5 kb were present in each of these tissues孤儿核受体PAR1抗体. Subunit: Heterodimer with RXR. Interacts with NCOA1. Subcellular Location: Nucleus. Tissue Specificity: Expressed in liver, colon and small intestine. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. Gene ID: 8856 Database links: Entrez Gene: 8856 Human Entrez Gene: 84385 Rat Omim: 603065 Human SwissProt: O75469 Human SwissProt:孤儿核受体PAR1抗体 Q9R1A7 Rat Unigene: 7303 Human Unigene: 207164 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
孤儿核受体PAR1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 染色质和核信号 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid