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COP9信号复合体亚基3抗体

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产品名称: COP9信号复合体亚基3抗体
产品型号: COPS3
产品展商: 单克隆抗体/多克隆抗体
产品文档: 无相关文档

简单介绍

COP9信号复合体亚基3抗体应用于IHC、WB、 IF、IP、ELISA等科研实验,按理化性质和生物学功能IgM、IgG、IgA、IgE、IgD五类。按抗体的来源,可将其分为天然抗体和**抗体。COP9信号复合体亚基3抗体生产每个流程都执行严格的检测标准,保证蛋白抗原产品质量,质量稳定,实验效果明显。


COP9信号复合体亚基3抗体  的详细介绍

COP9信号复合体亚基3抗体

规格:1mg/1ml

英文名: COPS3

别名: COP9 Signalosome Complex Subunit 3; CSN10; JAB1 Containing Signalosome Subunit 3; SGN3; Signalosome Subunit 3; CSN3_HUMAN.

分子量: 48kDa

储存液:Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M

克隆类型:Polyclonal

亚型:IgG

纯化方法:affinity purified by Protein A

**原:KLH conjugated synthetic peptide derived from human COPS3

交叉反应:Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,

细胞定位:细胞核 细胞浆

COP9信号复合体亚基3抗体产品介绍:background: The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]. Function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1COP9信号复合体亚基3抗体 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Subunit: Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COP6, COPS7 (COPS7A or COPS7B) and COPS8. In the complex, it probably interacts directly with COPS1, COPS4 and COPS8. Interacts with CK2 and PKD. Interacts with the translation initiation factor EIF3S6 and IKBKG. Subcellular Location: Cytoplasmic and Nuclear.COP9信号复合体亚基3抗体 Tissue Specificity: Widely expressed. Expressed at high level in heart and skeletal muscle. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the CSN3 family. Contains 1 PCI domain. Gene ID: 8533 Database links: Entrez Gene: 8533 Human Entrez Gene: 26572 Mouse Entrez Gene: 287367 Rat Omim: 604665 Human SwissProt: Q9UNS2 Human SwissProt: O88543 Mouse SwissProt: Q68FW9 Rat Unigene: 6076 Human Unigene: 40 Mouse Unigene: 3963 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

COP9信号复合体亚基3抗体产品应用:WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域:细胞生物  细胞周期蛋白  激酶和磷酸酶  

储存条件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源: Rabbit

外观: Lyophilized or Liquid


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