线粒体内膜转位酶8B
规格：1mg/1ml
英文名： TIMM8B
别名： DDP2; Deafness dystonia protein 2; FLJ21744; MGC102866; MGC117373; Mitochondrial import inner membrane translocase subunit Tim8 B; Small zinc finger like protein DDP2; TIM8B; ranslocase of inner mitoc
分子量： 9kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TIMM8B
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆 线粒体
线粒体内膜转位酶8B产品介绍：background: This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009] Function: Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM线粒体内膜转位酶8B complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). Subunit: Heterohexamer; possibly composed of 3 copies of TIMM8B and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22 (By similarity).线粒体内膜转位酶8B Subcellular Location: Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side. Tissue Specificity: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. Similarity: Belongs to the small Tim family. Gene ID: 26521 Database links: Entrez Gene: 26521 Human Entrez Gene: 30057 Mouse Entrez Gene: 64372 Rat Omim: 606659 Human SwissProt: Q9Y5J9 Human SwissProt: P62077 Mouse SwissProt: P62078 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
线粒体内膜转位酶8B产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 线粒体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid