剪切和多聚腺苷酸化特异性因子4抗体
规格：1mg/1ml
英文名： CPSF4
别名： Cleavage and polyadenylation specificity factor 30 kDa subunit; CPSF 30 kDa subunit; CPSF30; CPSF4; NAR; NEB1; No arches homolog; NS1 effector domain binding protein 1; CPSF4_RAT.
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CPSF4/CP
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
产剪切和多聚腺苷酸化特异性因子4抗体品介绍：background: Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants剪切和多聚腺苷酸化特异性因子4抗体 that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] Function: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U). Subunit: Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed 剪切和多聚腺苷酸化特异性因子4抗体of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with FIP1L1. Subcellular Location: Nucleus. Similarity: Belongs to the CPSF4/YTH1 family. Contains 5 C3H1-type zinc fingers. Contains 1 CCHC-type zinc finger. Gene ID: 10898 Database links: Entrez Gene: 10898 Human Entrez Gene: 54188 Mouse Entrez Gene: 304277 Rat Omim: 603052 Human SwissProt: O95639 Human SwissProt: Q8BQZ5 Mouse SwissProt: Q5FVR7 Rat Unigene: 489287 Human Unigene: 196884 Mouse Unigene: 104788 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
剪切和多聚腺苷酸化特异性因子4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid