MYSM1抗体
规格：1mg/1ml
英文名： MYSM1
别名： 2A-DUB; 2ADUB; Histone H2A deubiquitinase; Histone H2A deubiquitinase MYSM1; KIAA1915; Myb like SWIRM and MPN domains 1; Myb-like; Myb-like, SWIRM and MPN domains 1; MYSM 1; mysm1; MYSM1 Myb-like, SWI
分子量： 95kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MYSM1
交叉反应：Human, Mouse, Rat,
细胞定位：细胞核
MYSM1抗体产品介绍：background: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Function: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation MYSM1抗体and elongation steps of androgen receptor (AR)-induced gene activation. Subunit: Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones. Subcellular Location: Nucleus. Similarity: Belongs to the peptidase M67A family. MYSM1 subfamily. Contains 1 MPN (JAB/Mov34) domain. Contains 1 SANT domain. Contains 1 SWIRM domain. Gene ID: MYSM1抗体114803 Database links: Entrez Gene: 114803 Human Entrez Gene: 320713 Mouse Entrez Gene: 298247 Rat Omim: 612176 Human SwissProt: Q5VVJ2 Human SwissProt: Q69Z66 Mouse Unigene: 477495 Human Unigene: 208868 Mouse Unigene: 468748 Mouse Unigene: 63856 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产MYSM1抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 染色质和核信号 表观遗传学 泛素
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid