新朊蛋白抗体
规格：1mg/1ml
英文名： SPRN
别名： rCG47959; shadow of prion protein; SHO; Protein shadoo; bA108K14.1; C630041J07; FLJ41197; SPRN; Shadow of prion protein precursor; SPRN_MOUSE; SHADOO.
分子量： 12kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from mouse Shadow
交叉反应：Mouse, Rat,
细胞定位：细胞膜
新朊蛋白抗体产品介绍：background: Prion diseases, or transmissible spongiform encephalopathies (TSEs), are manifested as genetic, infectious or sporadic lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Constitutively expressed in normal ***** brain, cellular PrP (PrP(C)) is sensitive to proteinase K digestion and is converted to the disease form, PrPSc, through alterations in protein folding conformation, which make it resistant proteases. SPRN (shadow of prion protein), also known as SHO or SHADOO, is a 151 amino acid cytoplasmic protein that is mainly expressed in brain. SPRN is considered a prion-like protein that has PrP(C)-like neuroprotective activity and may act as a modulator for the biological actions of normal and abnormal PrP. In humans, mutations in the gene encoding SPRN may be associated with variant and sporadic Creutzfeldt-Jakob disease, a degenerative neurological disorder that is incurable and invariably fatal Function: Prion-like protein that 新朊蛋白抗体has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP. Subcellular Location: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Mainly expressed in brain (at protein level). In brain, it is highly expressed in the hippocampus and cerebellum and is also expressed at lower level in other areas of the brain including the cerebral cortex, the thalamus and the medulla. In hippocampus and cerebellum it is highly expressed in the cell bodies of pyramidal cells and Purkinje cells, respectively. Post-translational modifications:新朊蛋白抗体 N-glycosylated. Similarity: Belongs to the SPRN family. Gene ID: 212518 Database links: Entrez Gene: 212518 Mouse SwissProt: Q8BWU1 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 朊病毒蛋白（朊蛋白相关蛋白、沙杜蛋白）是导致动物脑细胞死亡的传染性病毒蛋白，是一种致病性神经蛋白。 朊蛋白相关蛋白Shadoo是近期才被发行的新朊蛋白，其传播、传染过程尚不清楚，发病机理还有待于研究中。
新朊蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞凋亡 **及病毒
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid