血管紧张素Ⅱ受体2抗体
规格：1mg/1ml
英文名： AT2R2
别名： AGTR 2; AGTR2; AGTR-2; AGTR2_HUMAN; angiotensin II receptor type 2; Angiotensin II Type 2; Angiotensin II type-2 receptor; Angiotensin receptor 2; AT 2; AT2; AT2R2 ATGR 2; ATGR2; ATGR-2; MRX 88; MRX88
分子量： 41kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human angioten
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Sheep,
细胞定位：细胞膜
血管紧张素Ⅱ受体2抗体产品介绍：background: Angiotensin II (Ang II) is an important physiological effector of blood pressure and volume regulation through vasoconstriction, aldosterone release, sodium uptake and thirst stimulation. Although Ang II interacts with two types of cell surface receptors, AT1 and AT2, most of the major cardiovascular effects seem to be mediated through AT1. Molecular cloning of the AT1 protein has shown it to be a member of the G protein-associated seven transmembrane protein receptor family. Ang II treatment of cells results in activation of several signal transduction pathways as evidenced by tyrosine phosphorylation of several proteins and induction of others. PLC?is phosphorylated after 30 seconds of treatment with Angiotensin II, indicating this as an early signal transduction event. Ang II treatment also stimulates phosphorylation of Shc, FAK and MAP kinases, and induces MKP-1, indicating stimulation of growth factor pathways. Ang II stimulation through AT1 has been shown to activate the JAK/Stat pathway involving a direct interaction between JAK2 and AT1 as demonstrated by coimmunoprecipitation. 血管紧张素Ⅱ受体2抗体The AT1 receptor has no cytoplasmic kinase domain, but is able to function as a substrate for Src kinases and has several putative phosphorylation sites. Function: Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. Subunit: Interacts with MTUS1. Subcellular Location: Cell membrane. Tissue Specificity: In *****, highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. Very highly expressed in fetal kidney and intestine. DISEASE: Defects in AGTR2 are the cause of mental retardation X-linked type 88 (MRX88) [MIM:300852]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in 血管紧张素Ⅱ受体2抗体adaptative behavior and manifested during the developmental period. Similarity: Belongs to the G-protein coupled receptor 1 family. Gene ID: 186 Database links: Entrez Gene: 186 Human Entrez Gene: 11609 Mouse Entrez Gene: 24182 Rat Omim: 300034 Human SwissProt: P50052 Human SwissProt: P35374 Mouse SwissProt: Q3US12 Mouse SwissProt: P35351 Rat Unigene: 405348 Human Unigene: 2679 Mouse Unigene: 162367 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
血管紧张素Ⅱ受体2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 信号转导 G蛋白偶联受体
储存条件： Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid