跨膜蛋白TMEM16K抗体
规格：1mg/1ml
英文名： TMEM16K
别名： ANO10; Anoctamin 10; FLJ10375; Hypothetical protein LOC55129; MGC47890; TMEM 16K; Transmembrane protein 16K.
分子量： 77kDa
储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TMEM16K
交叉反应：Human, Mouse, Rat, Cow,
细胞定位：细胞膜
跨膜蛋白TMEM16K抗体产品介绍：background: TMEM16K is a multi-pass membrane protein. It belongs to the anoctamin family and may act as a calcium-activated chloride channel. There are two named isoforms. Function: Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in the brain. Intermediate levels in the retina and heart and low levels in the placenta, liver, lung, duodenum, kidney, testis and spleen. In brain areas, highest expression in the frontal and occipital cortices and in the cerebellum. Lower expression in the fetal brain than in the ***** brain. DISEASE: The disease is caused by mutations affecting the gene represented in this entry. Disease description:Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination 跨膜蛋白TMEM16K抗体of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR10 is characterized by onset in the teenage or young ***** years of gait and limb ataxia, dysarthria, and nystagmus associated with marked cerebellar atrophy on brain imaging. Similarity: Belongs to the anoctamin family. Database links: Entrez Gene: 534290 Cow 跨膜蛋白TMEM16K抗体Entrez Gene: 55129 Human Entrez Gene: 102566 Mouse Entrez Gene: 301111 Rat SwissProt: A7MBF4 Cow SwissProt: Q9NW15 Human SwissProt: Q8BH79 Mouse Unigene: 656657 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
跨膜蛋白TMEM16K抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 神经生物学 跨膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid